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Preheat the oven to 350°F. Set the oven rack to the center position.
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Let the brisket sit at room temperature for 20 minutes.
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Pat brisket dry with paper towel. Season the Brisket on all sides with a total of 2
teaspoons salt and 1⁄4 teaspoon pepper.
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Heat a large oven-safe skillet (with high-sides) over medium-high heat. Add 1 tablespoon
of avocado oil and heat for 1 minute. Add the brisket to the pan and sear for about 5-7 minutes on each side until golden brown. Transfer the brisket to a large plate and set aside.
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To the pan, add remaining 1 1⁄2 tablespoon of oil and sliced onion and cook over medium-low heat for 5 minutes or until they begin to soften. Use a wooden spoon to scrape any browned bits from the bottom of the pan and mix into the onions. Add the minced garlic and cook for 1 minute.
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Mix in the remaining 1 teaspoon salt, 1⁄2 teaspoon pepper, paprika, cumin, red wine, broth, brown sugar and ketchup.
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Nestle the brisket (and any of its juices from the plate) into the liquid-onion mixture and spoon the liquid-onion mixture over the brisket.
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Bring the liquid in the pan to a boil over high heat. Then, turn off the heat, cover the pan with an oven-safe lid and place the skillet in the oven and bake for 3-4 hours or until the meat is soft and pulls apart relatively easily.
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Turn the oven off, open the oven door slightly, let sit for 30 minutes to help it begin to cool down.
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Carefully take the pan out of the oven (make sure to keep an oven mitt or towel on the handle of the pan so you don’t accidentally get confused and burn yourself) and let cook completely.
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Place the brisket onto a cutting board and slice the brisket against the grain into 1⁄2” thick slices. Transfer back to the sauce.
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Refrigerate the cooked sliced brisket in the sauce covered overnight for the most tender & juicy results. I like to transfer the brisket to a 9”x13” pan at this point for easy fridge storage & reheating, and cover with parchment then foil.
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When ready to serve, turn the oven to 350°F and place the pan of sliced brisket into the oven for 30 minutes to warm up until fully heated through.